Seven children and one woman were among the dead in the village of Khasham near the city of Deir al-Zour, which is controlled by ISIS militants.
The death toll was reported by the Syrian Observatory for Human Rights, the biggest organisation tracking developments on the ground in the war-torn country.
There are around 200,000 still living inside Deir al-Zour, which is largely controlled by ISIS militants
The Observatory said the death toll was likely to rise as ‘dozens’ more people were wounded.
On Friday, air strikes killed at least 44 civilians in Tabiyyah Jazeera, a village next to Khasham.
It was unclear if those raids were carried out by Russian or regime warplanes.
The latest strikes come as Syria’s government pushes to retake territory captured by ISIS after a fierce offensive by the militants last week.
The multi-front assault on Deir al-Zour and subsequent fighting has left nearly 500 people dead, according to the Observatory.
While ISIS controls most of the oil-rich province, the Syrian government has clung onto parts of the provincial capital, as well as the nearby military airport.
There are around 200,000 still living inside the city. The UN has recently warned of ‘sharply deteriorating’ conditions there.
The multi-front assault on Deir al-Zour and subsequent fighting has left nearly 500 people dead
Russia, a staunch ally of tyrannical President Bashar al-Assad’s government, began an air campaign and a build-up of troops on the ground in support of Damascus four months ago.
Western governments have claimed unguided Russian munitions have caused hundreds of civilian deaths – a claim which Russia denies.
Elsewhere, in the ISIS-stronghold of Raqqa, at least 32 people were reported dead.